Author:
Cereda Alberto,Toselli Marco,Palmisano Anna,Vignale Davide,Leone Riccardo,Nicoletti Valeria,Gnasso Chiara,Mangieri Antonio,Khokhar Arif,Campo Gianluca,Scoccia Alessandra,Bertini Matteo,Loffi Marco,Sergio Pietro,Andreini Daniele,Pontone Gianluca,Iannopollo Gianmarco,Nannini Tommaso,Ippolito Davide,Bellani Giacomo,Patelli Gianluigi,Besana Francesca,Vignali Luigi,Sverzellati Nicola,Iannaccone Mario,Vaudano Paolo Giacomo,Sangiorgi Giuseppe Massimo,Turchio Piergiorgio,Monello Alberto,Tumminello Gabriele,Maggioni Aldo Pietro,Rapezzi Claudio,Colombo Antonio,Giannini Francesco,Esposito Antonio
Abstract
AbstractRecent clinical and demographical studies on COVID-19 patients have demonstrated that men experience worse outcomes than women. However, in most cases, the data were not stratified according to gender, limiting the understanding of the real impact of gender on outcomes. This study aimed to evaluate the disaggregated in-hospital outcomes and explore the possible interactions between gender and cardiovascular calcifications. Data was derived from the sCORE-COVID-19 registry, an Italian multicentre registry that enrolled COVID-19 patients who had undergone a chest computer tomography scan on admission. A total of 1683 hospitalized patients (mean age 67±14 years) were included. Men had a higher prevalence of cardiovascular comorbidities, a higher pneumonia extension, more coronary calcifications (63% vs.50.9%, p<0.001), and a higher coronary calcium score (391±847 vs. 171±479 mm3, p<0.001). Men experienced a significantly higher mortality rate (24.4% vs. 17%, p=0.001), but the death event tended to occur earlier in women (15±7 vs. 8±7 days, p= 0.07). Non-survivors had a higher coronary, thoracic aorta, and aortic valve calcium score. Female sex, a known independent predictor of a favorable outcome in SARS-CoV2 infection, was not protective in women with a coronary calcification volume greater than 100 mm3. There were significant differences in cardiovascular comorbidities and vascular calcifications between men and women with SARS-CoV2 pneumonia. The differences in outcomes can be at least partially explained by the different cardiovascular profiles. However, women with poor outcomes had the same coronary calcific burden as men. The presumed favorable female sex bias in COVID-19 must therefore be reviewed in the context of comorbidities, especially cardiovascular ones.
Funder
Università degli Studi di Ferrara
Publisher
Springer Science and Business Media LLC
Subject
Geriatrics and Gerontology,Aging