Affiliation:
1. Department of Biochemistry, University of Oxford, Oxford OX1 3QU, U.K.
Abstract
Rats given an LD50 dose of Be2+ showed reduced activities of ornithine decarboxytase and tyrosine aminotransferase in liver in response to dexamethasone induction. Control fed animals showed ‘superinduction’. Be2+ also inhibited the uptake of [3H]orotic acid into rapidly labelled RNA of ribonucleoprotein particles extracted from liver nuclei in isomolar solutions at pH 8.0. Consistent with inhibition of cytoplasmic protein kinase reported previously (Kaser et at., 1980), the uptake of [32P]Pi into proteins in the ribonucleoprotein particles was also diminished.
Subject
Cell Biology,Molecular Biology,Biochemistry,Biophysics
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