Abstract
AbstractEnterococci are commensals of human and other animals’ gastrointestinal tracts. Only making up a small part of the microbiota, they have not played a significant role in research, until the 1980s. Although the exact year is variable according to different geographical areas, this was the decade when vancomycin-resistant enterococci (VRE) were discovered and since then their role as causative agents of human infections has increased. Enterococcus faecium is on the WHO’s list of “bacteria for which new antibiotics are urgently needed,” and with no new antibiotics in development, the situation is desperate. In this review, different aspects of VRE are outlined, including the mortality caused by VRE, antibiotic resistance profiles, animal-modeling efforts, and virulence. In addition, the limitations of current antibiotic treatments for VRE and prospective new treatments, such as bacteriocins, are reviewed.
Funder
Research council of Norway
H2020 European Research Council
Publisher
Springer Science and Business Media LLC
Subject
Molecular Biology,Molecular Medicine,Microbiology
Reference129 articles.
1. Aarestrup FM, Agerso Y, Gerner-Smidt P, Madsen M, Jensen LB (2000) Comparison of antimicrobial resistance phenotypes and resistance genes in Enterococcus faecalis and Enterococcus faecium from humans in the community, broilers, and pigs in Denmark. Diagn Microbiol Infect Dis 37(2):127–137
2. Abele-Horn M, Vogel U, Klare I, Konstabel C, Trabold R, Kurihara R, Witte W, Kreth W, Schlegel PG, Claus H (2006) Molecular epidemiology of hospital-acquired vancomycin-resistant enterococci. J Clin Microbiol 44(11):4009–4013. https://doi.org/10.1128/JCM.00195-06
3. Adams DJ, Eberly MD, Goudie A, Nylund CM (2016) Rising vancomycin-resistant Enterococcus infections in hospitalized children in the United States. Hosp Pediatr 6(7):404–411. https://doi.org/10.1542/hpeds.2015-0196
4. Akhtar N, Sultan F, Nizamuddin S, Zafar W (2016) Risk factors and clinical outcomes for vancomycin-resistant Enterococcus bacteraemia in hospitalised cancer patients in Pakistan: a case-control study. J Pak Med Assoc 66(7):829–836
5. Akiyama Y, Kanehara K, Ito K (2004) RseP (YaeL), an Escherichia coli RIP protease, cleaves transmembrane sequences. EMBO J 23(22):4434–4442. https://doi.org/10.1038/sj.emboj.7600449
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