Author:
Pfeffer Tobias J.,Pietzsch Stefan,Hilfiker-Kleiner Denise
Abstract
AbstractCardiovascular diseases and cancer are major causes of mortality in industrialized societies. They share common risk factors (e.g., genetics, lifestyle, age, infection, toxins, and pollution) and might also mutually promote the onset of the respective other disease. Cancer can affect cardiac function directly while antitumor therapies may have acute- and/or late-onset cardiotoxic effects. Recent studies suggest that heart failure might promote tumorigenesis and tumor progression. In both cancer and cardiovascular diseases, genetic predisposition is implicated in the disease onset and development. In this regard, genetic variants classically associated with cardiomyopathies increase the risk for toxic side effects on the cardiovascular system. Genetic variants associated with increased cancer risk are frequent in patients with peripartum cardiomyopathy complicated by cancer, pointing to a common genetic predisposition for both diseases. Common risk factors, cardiotoxic antitumor treatment, genetic variants (associated with cardiomyopathies and/or cancer), and increased cardiac stress lead us to propose the “multi-hit hypothesis” linking cancer and cardiovascular diseases. In the present review, we summarize the current knowledge on potential connecting factors between cancer and cardiovascular diseases with a major focus on the role of genetic predisposition and its implication for individual therapeutic strategies and risk assessment in the novel field of oncocardiology.
Publisher
Springer Science and Business Media LLC
Subject
Cardiology and Cardiovascular Medicine
Reference40 articles.
1. World Health Organisation (2016) Global health estimates 2015: deaths by cause, age, sex, by country and by region, 2000–2015
2. Petek BJ, Greenman C, Herrmann J, Ewer MS, Jones RL (2015) Cardio-oncology: an ongoing evolution. Future Oncol 11(14):2059–2066
3. Habibian M, Lyon AR (2019) Monitoring the heart during cancer therapy. Eur Heart J Suppl 21(Suppl M):M44–M49
4. Meijers WC, Maglione M, Bakker SJL et al (2018) Heart failure stimulates tumor growth by circulating factors. Circulation 138(7):678–691
5. Pfeffer TJ, Schlothauer S, Pietzsch S et al (2019) Increased cancer prevalence in peripartum cardiomyopathy. JACC CardioOncol 1(2):196–205
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