Different effects of chlorpromazine on bleomycin-and epirubicin induced cytotoxicity-Reference-Cited by-同舟云学术

Different effects of chlorpromazine on bleomycin-and epirubicin induced cytotoxicity

Published:1990-04-01 Issue:2 Volume:10 Page:173-177
ISSN:0144-8463
Container-title:Bioscience Reports
language:en
Short-container-title:

Author:

Grankvist Kjell¹,Bergström Per¹,Henriksson Roger¹

Affiliation:

1. Departments of Clinical Chemistry, and Oncology, Umeå University Hospital, S-901 85 UMEÅ, Sweden

Abstract

The effect of the antiemetic chlorpromazine on bleomycin- and epirubicin cytotoxicity was tested in vitro. Chlorpromazine (0.1 or 0.01 mg/l) enhanced epirubicin-induced toxicity to cultured Chinese fibroblasts whereas 0.01 mg/l chlorpromazine inhibited the cytotoxicity of bleomycin. The results encourage further studies on the effects of commonly used antiemetics on the cytotoxicity and antitumoral effects of anticancer chemotherapeutics.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Link

https://portlandpress.com/bioscirep/article-pdf/10/2/173/468111/bsr0100173.pdf

Reference12 articles.

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3. Grankvist, K. and Henriksson, R. (1987)Biosci. Rep. 7:653?658.

4. Henriksson, R. and Grankvist, K. (1988)Med. Oncol. Tumor. Pharmacother. 6:175?178.

5. Inaba, M. (1986)Progr. Clin. Biol. Res. 223:35?44.

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