Interaction of thymic peptide thymosin α1 with vasoactive intestinal peptide (VIP) receptors
Author:
Calvo J. R.1, Goberna R.1, Guerrero J. M.1
Affiliation:
1. Dept. de Bioquímica, Facultad de Medicina, Avda. Sánchez Pizjuán, 4, 41009-SEVILLA, Spain
Abstract
Thymic peptide thymosin α1 (10−9 to 3 × 1010−7 M) is shown to inhibit the specific binding of [125I]VIP to rat blood mononuclear cells and liver plasma membranes. Thymosin α1 was 160 and 6250 times less potent that VIP at inhibiting [125I]VIP binding to blood mononuclear cells and liver plasma membranes, respectively. Thymosin α1 (10−10 to 1010−7 M) was weak in stimulating adenylate cyclase activity. Its efficacy is about 25 % and 27 % that of native VIP in blood mononuclear cells and liver plasma membranes, respectively. Thymosin α1 may behave as a partial VIP agonist in rat.
Publisher
Portland Press Ltd.
Subject
Cell Biology,Molecular Biology,Biochemistry,Biophysics
Reference34 articles.
1. Goldstein, A. L., Low, T. L. K., McAdoo, M., McClure, J., Thurman, G. B., Rossio, J. L., Lai, C-Y., Chang, D., Wang, S-S., Harvey, C., Ramel, A. H., and Meienhofer, J. (1977).Proc. Natl. Acad. Sci. USA 74:725?729. 2. Hooper, J. A., McDaniel, M. C., Thurman, G. B., Cohen, G. H., Schulof, R. S. and Goldstein, A. L. (1975).Ann. NY Acad. Sci. 249:125?144. 3. Low, T. L. K., Thurman, G. B., McAdoo, M., McClure, J., Rossio, J., Naylor, P. H. and Goldstein, A. L. (1979).J. Biol. Chem. 254:981?986. 4. Low, T. L. K. and Goldstein, A. L. (1979).J. Biol. Chem. 254:987?995. 5. Guillemin, R., Brazeau, P., Böhlen, P., Esch, F., Ling, N. and Wehrenberg, W. B. (1982).Science 218:585?587.
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
|
|