Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Biochemistry
Link
http://link.springer.com/article/10.1007/s12192-018-0877-2/fulltext.html
Reference138 articles.
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3. Allan RK, Mok D, Ward BK, Ratajczak T (2006) Modulation of chaperone function and cochaperone interaction by novobiocin in the C-terminal domain of Hsp90: evidence that coumarin antibiotics disrupt Hsp90 dimerization. J Biol Chem 281(11):7161–7171. https://doi.org/10.1074/jbc.M512406200
4. Anckar J, Sistonen L (2011) Regulation of HSF1 function in the heat stress response: implications in aging and disease. Annu Rev Biochem 80(1):1089–1115. https://doi.org/10.1146/annurev-biochem-060809-095203
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