Abstract
AbstractStreptococcus pneumoniae (SP) infections cause morbidity and mortality among children worldwide. Hence India introduced 13-valent pneumococcal conjugate vaccine (PCV-13) in 2017 in a phased manner. The primary objective of this study was to assess the proportion of healthy children having nasopharyngeal colonization (NP) with SP. Secondary objective was to determine prevalent serotype of SP among the PCV13 vaccinated and non-vaccinated children. This cross-sectional study was conducted in 4 hospitals of Lucknow District, Northern India. Three hundred healthy children (2–59 months) were recruited between July and August 2019 from vaccination-clinics of hospitals. NP specimen was cultured using 5% sheep blood agar plate containing gentamicin. Pneumococcal isolates were identified by optochin sensitivity and bile-solubility tests. Serotyping was done using Quellung Method. Of the 300 healthy children, 56.7% (170/300) were males and 59.3% (181/300) had received at least one dose of PCV13 vaccine. The NP carriage rate of SP among healthy children was 37.7% (113/300). Vaccine serotypes were found in 33.3% (22/66) in PCV vaccinated children and 48.9% (23/47) in non-vaccinated children (p 0.09). Common vaccine serotypes that isolated were: 18C, 19A, 19F, 23F, 3, 4, 6A, 6B, 9 V. Thus more than one-third of healthy children had NP colonization with SP. Adjusting for age, there was a trend for significant reduction in vaccine serotypes in the NP with one doses versus two or more doses (ptrend = 0.04).
Funder
Bill and Melinda Gates Foundation
Publisher
Springer Science and Business Media LLC
Subject
Applied Microbiology and Biotechnology,General Medicine,Microbiology
Reference56 articles.
1. Houri H, Tabatabaei SR, Saee Y, Fallah F, Rahbar M et al (2017) Distribution of capsular types and drug resistance patterns of invasive pediatricStreptococcus pneumoniae isolates in Teheran, Iran. Int J Infect Dis 57:21–26. https://doi.org/10.1016/j.ijid.2017.01.020
2. Loughran AJ, Orihuela CJ, Tuomanen EI (2019) Streptococcus pneumoniae: invasion and inflammation. Microbiol Spectrum 7(2):7–2
3. Ministry of health and family welfare, Government of India. Available at: https://nhm.gov.in/New_Updates_2018/NHM_Components/Immunization/Guildelines_for_immunization/Operational_Guidelines_for_PCV_introduction.pdf. Accessed on 10th Sep., 2021
4. Fighting for breath call to action: End childhood pneumonia deaths (Report). The Global Forum on childhood pneumonia. 2021. Available at: https://stoppneumonia.org/wp-content/uploads/2019/11/Fighting-for-Breath-briefing-8th-pp-low-res_rev-20-Nov.pdf Assessed on: August 1, 2021
5. Song JY, Nahm MH, Moseley MA (2013) Clinical implications of pneumococcal serotypes: invasive disease potential, clinical presentations, and antibiotic resistance. J Korean Med Sci 28(1):4–15. https://doi.org/10.3346/jkms.2013.28.1.4
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献