Studies on the secondary metabolism of Rosellinia and Dematophora strains (Xylariaceae) from Iran

Author:

Pourmoghaddam Mohammad Javad,Ekiz Güner,Lambert Christopher,Surup Frank,Primahana Gian,Wittstein Kathrin,Khodaparast Seyed Akbar,Voglmayr Hermann,Krisai-Greilhuber Irmgard,Stradal Theresia E. B.,Stadler MarcORCID

Abstract

AbstractThe xylariaceous genus Dematophora has recently been resurrected and segregated from Rosellinia based on a molecular phylogeny and morphological characters. This was an important taxonomic change because Dematophora in the current sense contains several important pathogens, while Rosellinia is limited to mainly saprotrophic species that have an endophytic stage in their life cycle and may even have beneficial effects on the host plants. During our ongoing work on the functional biodiversity of the Xylariales, we have encountered new strains of rosellinoid Xylariaceae from Iran and have studied their mycelial cultures for secondary metabolites in an attempt to establish further chemotaxonomic affinities. In the process, we isolated and identified 13 compounds, of which rosellisteroid (1), the cichorine derivative 2, and the alkaloid 3 are new. Out of these, nine were tested for their antimicrobial affinities with cytochalasin E (6) exhibiting weak activity against Schizosaccharomyces pombe. The cytotoxicity of three cytochalasin derivatives was examined and their effects on the F-actin cytoskeletal organization studied by fluorescence microscopy using fluorescent phalloidin. Cytochalasin E (6) and Δ6,12-cytochalasin E (7) showed strong and irreversible action on actin, while cytochalasin K (8) exhibited weaker, reversible effects.

Funder

DFG

Iranian Council of Stem Cell Research and Technology

Life Science Foundation

DAAD

Publisher

Springer Science and Business Media LLC

Subject

Agricultural and Biological Sciences (miscellaneous),Ecology, Evolution, Behavior and Systematics

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