Design, synthesis and evaluation of amino-3,5-dicyanopyridines and thieno[2,3-b]pyridines as ligands of adenosine A1 receptors for the potential treatment of epilepsy-Reference-Cited by-同舟云学术

Design, synthesis and evaluation of amino-3,5-dicyanopyridines and thieno[2,3-b]pyridines as ligands of adenosine A1 receptors for the potential treatment of epilepsy

Published:2022-05-24 Issue:8 Volume:31 Page:1277-1297
ISSN:1054-2523
Container-title:Medicinal Chemistry Research
language:en
Short-container-title:Med Chem Res

Author:

Nkomba Gaofenngwe,Terre’Blanche Gisella,Janse van Rensburg Helena D.^ORCID,Legoabe Lesetja J.

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics

Link

https://link.springer.com/content/pdf/10.1007/s00044-022-02908-9.pdf

Reference81 articles.

1. Sheth S, Brito R, Mukherjea D, Rybak LP, Ramkumar V. Adenosine receptors: expression, function and regulation. Int J Mol Sci. 2014;15:2024–52.

2. Jacobson KA, Gao ZG. Adenosine receptors as therapeutic targets. Nat Rev Drug Discov. 2006;5:247–64.

3. Abbracchio MP, Cattabeni F. Brain adenosine receptors as targets for therapeutic intervention in neurodegenerative diseases. Ann N. Y Acad Sci. 1999;890:79–92.

4. Chen JF, Eltzschig HK, Fredholm BB. Adenosine receptors as drug targets–what are the challenges? Nat Rev Drug Discov. 2013;12:265–86.

5. Effendi WI, Nagano T, Kobayashi K, Nishimura Y. Focusing on adenosine receptors as a potential targeted therapy in human diseases. Cells. 2020;9:1–36.

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Recent advancements in the synthesis of fused thienopyridines and their therapeutic applications;European Journal of Medicinal Chemistry Reports;2024-12

2. Syntheses and Biological Activities of Tricyclic-fused Quinoxaline Ring Systems (A Review). Part I: Thienoquinoxalines;INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY;2024-06

3. Utility of 2-Chloro-N-arylacetamide and 1,1′-(Piperazine-1,4-diyl)bis(2-chloroethanone) as Versatile Precursors for Novel Mono- and Bis[thienopyridines];ACS Omega;2024-02-21

4. Synthesis and structure of 4-aryl-3,6-dioxo-2,3,4,5,6,7-hexahydroisothiazolo[5,4-<i>b</i>]pyridine-5-carbonitriles;Журнал общей химии;2023-01-15

5. Six-membered ring systems: pyridines and benzo derivatives;Progress in Heterocyclic Chemistry;2023