In vitro and in silico evaluations of new aryloxy-1,4-naphthoquinones as anti-Trypanosoma cruzi agents

Author:

González Alejandra,Becerra Nohemí,Kashif Muhammad,González Mercedes,Cerecetto Hugo,Aguilera Elena,Nogueda-Torres Benjamín,Chacón-Vargas Karla F.,José Zarate-Ramos J.,Castillo-Velázquez Uziel,Salas Cristian O.,Rivera Gildardo,Vázquez KarinaORCID

Funder

Universidad Autónoma de Nuevo León

Secretaría de Investigación y Posgrado, Instituto Politécnico Nacional

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics

Reference28 articles.

1. Álvarez G, Varela J, Márquez P, Gabay M, Arias Rivas CE, Cuchilla K, Echeverría GA, Piro OE, Chorilli M, Leal SM, Escobar P, Serna E, Torres S, Yaluff NIG, Vera de Bilbao, González M, Cerecetto H (2014) Optimization of antitrypanosomatid agents: identification of nonmutagenic drug candidates with in vivo activity. J Med Chem 57:3984–3999

2. Bolognesi ML, Lizzi F, Perozzo R, Brunc R, Cavallia A (2008) Synthesis of a small library of 2-phenoxy-1,4-naphthoquinone and 2-phenoxy-1,4-anthraquinone derivatives bearing anti-trypanosomal and anti-leishmanial activity. Bioorg Med Chem Lett 18:2272–2276

3. Bombaca AC, Viana PG, Santos ACC, Silva TL, Rodrigues ABM, Guimaraes ACR, Goulart MOF, Da Silva EN,Jr, Menna-Barreto RFS(2019) Mitochondrial dysfunction and ROS production are essential for anti- Trypanosoma cruzi activity of β-lapachone-derived naphthoimidazoles Free Radic Biol Med 130:408–418

4. Chacón-Vargas KF, Nogueda-Torres B, Sánchez-Torres LE, Erick Suarez-Contreras E, Villalobos-Rocha JC, Torres-Martinez Y, Lara-Ramirez EE, Giulia F, Krauth-Siegel RL, Bolognesi ML, Monge A, Rivera G (2017) Trypanocidal activity of quinoxaline 1,4-di-N-oxide derivatives as Trypanothione Reductase inhibitors. Molecules 22:220–237

5. Da Silva Jr EN, Jardim Guilherme AM, Menna-Barreto Rubem FS, De Castro Solange L (2014) Anti-Trypanosoma cruzi compounds: our contribution for the evaluation and insights on the mode of action of naphthoquinones and derivatives. J Braz Chem Soc 25:1780–1798

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