Synthesis, 5-HT1A and 5-HT2A receptor affinity and QSAR study of 1-benzhydryl-piperazine derivatives with xanthine moiety at N4

Author:

Valkova Iva,Zlatkov Alexander,Nędza Krystyna,Doytchinova Irini

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics

Reference27 articles.

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3. Bojarski AJ, Cegła MT, Charakchieva-Minol S, Mokrosz MJ, Mackowiak M, Mokrosz JL (1993) Structure-activity relationship studies of CNS agents. Part 9. 5-HT1A and 5-HT2 receptor affinity of some 2- and 3-substituted 1,2,3,4-tetrahydro-β-carbolines. Pharmazie 48:289–294

4. Cheng Y, Prusoff WH (1973) Relationship between the inhibition constant ([K.sub.i]) and the concentration of inhibitor which causes 50 per cent inhibition ([I.sub.50]) of an enzymatic reaction. Biochem Pharmacol 22:3099–3108

5. Chlon G, Pawlowski M, Duszynska B, Szaro A, Tatarczynska E, Klodzinska A, Chojnacka-Wojcik E (2001) Synthesis, 5-HT1A and 5-HT2A receptor activity of new 1-phenylpiperazinylpropyl derivatives with arylalkyl substituents in position 7 of purine-2, 6-dione. Pol J Pharmacol 53:359–368

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