Pharmacophore modeling, 3DQSAR, and docking-based design of polysubstituted quinolines derivatives as inhibitors of phosphodiesterase 4, and preliminary evaluation of their anti-asthmatic potential

Author:

Gaurav Anand,Singh Ranjit

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics

Reference41 articles.

1. Alon R, Ley K (2008) Cells on the run: shear-regulated integrin activation in leukocyte rolling and arrest on endothelial cells. Curr Opin Cell Biol 20(5):525–532

2. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE (1998) Catalytic domain of human phosphodiesterase 4B2B in complex with a quinoline inhibitor. RCSB Protein Data Bank

3. Castillo E, Beer SD (1947) THE TRACHEAL CHAIN: I. A preparation for the study of antispasmodics with particular reference to bronchodilator drugs. J Pharmacol Exp Ther 90(2):104–110

4. Chakraborti AK, Gopalakrishnan B, Sobhia ME, Malde A (2003a) 3D-QSAR studies of indole derivatives as phosphodiesterase IV inhibitors. Eur J Med Chem 38(11):975–982

5. Chakraborti AK, Gopalakrishnan B, Sobhia ME, Malde A (2003b) 3D-QSAR studies on thieno[3,2-d]pyrimidines as phosphodiesterase IV inhibitors. Bioorg Med Chem Lett 13(8):1403–1408

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