Synthesis and biological evaluation of new thiazolyl-urea derivatives as potential dual C-RAF/FLT3 inhibitors-Reference-Cited by-同舟云学术

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Synthesis and biological evaluation of new thiazolyl-urea derivatives as potential dual C-RAF/FLT3 inhibitors

Published:2022-09-20 Issue:11 Volume:31 Page:1862-1874
ISSN:1054-2523
Container-title:Medicinal Chemistry Research
language:en
Short-container-title:Med Chem Res

Author:

Zhang Zhi-Hua,Zeng Bi-Fan,Song Zhe-Xue,Yang Ying-Yu,Zhang Kai-yun,Du Xue,Zhang Lin-lin,Cai Dong^ORCID

Funder

the financial support from the Natural Science Foundation of Liaoning Province

Natural Science Foundation of Liaoning Province

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics

Link

https://link.springer.com/content/pdf/10.1007/s00044-022-02971-2.pdf

Reference26 articles.

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2. Ballantyne AD, Garnock-Jones KP. Dabrafenib: first global approval. Drugs. 2013;73:1367–76. https://doi.org/10.1007/s40265-013-0095-2.

3. Andre F, Ciruelos E, Rubovszky G, Campone M, Loibl S, Rugo HS. et al. Alpelisib for PIK3CA-mutated, hormone receptor–positive advanced breast cancer. N. Engl J Med. 2019;380:1929–40. https://doi.org/10.1056/NEJMoa1813904.

4. Wang S, Midgley CA, Scaërou F, Grabarek JB, Griffiths G, Jackson W. et al. Discovery of N-phenyl-4-(thiazol-5-yl) pyrimidin-2-amine aurora kinase inhibitors. J Med Chem. 2010;53:4367–78. https://doi.org/10.1021/jm901913s.

5. Alizadeh SR, Hashemi SM. Development and therapeutic potential of 2-aminothiazole derivatives in anticancer drug discovery. Med Chem Res. 2021;30:771–806. https://doi.org/10.1007/s00044-020-02686-2.

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1. Design, synthesis, and antitumor activities of novel ureido/thioureido derivatives with a 4-phenylthiazol-2-amine scaffold;Journal of Saudi Chemical Society;2024-07

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