Novel 2-(E)-substituted benzylidene-6-(N-substituted aminomethyl)cyclohexanones and cyclohexanols as analgesic and anti-inflammatory agents

Author:

Liu Dan,Yu Weishe,Li Jingjing,Pang Cong,Zhao Linxiang

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics

Reference14 articles.

1. Ao GZ, Zhang YH, Ji H et al (2004) Synthesis and anti-inflammatory activity of p-(methanesulfonyl) styrene-linked cyclic ketone derivatives. Acta Pharmaceutica Sin 39:803–807

2. Brand S, de Candole BC, Brown JA (2003) Efficient synthesis of 3-aminocyclobut-2-en-1-ones: squaramide surrogates as potent VLA-4 antagonists. Org Lett 5:2343–2346

3. Das U, Doroudi A, Das S et al (2008) E, E-2-benzylidene-6-(nitrobenzylidene)cyclohexanones: syntheses, cytotoxicity and an examination of some of their electronic, steric, and hydrophobic properties. Bioorg Med Chem 16:6261–6268

4. Falck JR, He A, Reddy LM et al (2006) Ring expansion/homologation-aldehyde condensation cascade using tert-trihalomethylcarbinols. Org Lett 8:4645–4647

5. Gaudry M, Jasor Y, Bui Khac T (1988) Regioselective mannich condensation with dimethyl(methylene) ammonium trifluoroacetate: 1-(dimethylamino)-4-methyl-3-pentanone. Org. Synth.6(CV), vol 2. ACS, New York, pp 470–471

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