1,4-Disubstituted-5-hydroxy-3-methylpyrazoles and some derived ring systems as cytotoxic and DNA binding agents. Synthesis, in vitro biological evaluation and in silico ADME study-Reference-Cited by-同舟云学术

1,4-Disubstituted-5-hydroxy-3-methylpyrazoles and some derived ring systems as cytotoxic and DNA binding agents. Synthesis, in vitro biological evaluation and in silico ADME study

Published:2017-09-21 Issue:2 Volume:27 Page:442-457
ISSN:1054-2523
Container-title:Medicinal Chemistry Research
language:en
Short-container-title:Med Chem Res

Author:

Hany Badr Mona^ORCID,Abd El Razik Heba Attia

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics

Link

http://link.springer.com/article/10.1007/s00044-017-2071-y/fulltext.html

Reference55 articles.

1. Abbate F, Casini A, Owa T, Scozzafava A, Supuran CT (2004) Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Bioorg Med Chem Lett 14:217–223

2. Ait‐Baziz N, Rachedi Y, Silva AMS (2010) Reactivity of some structural analogs of dehydroacetic acid with o-phenylenediamine. Arkivoc 10:86–97

3. Al-Said MS, Ghorab MM, Al-Qasoumi SI, El-Hossary EM, Noaman E (2010) Synthesis and in vitro anticancer screening of some novel 4-[2-amino-3-cyano-4-substituted-5,6,7,8-tetrahydroquinolin-1-(4H)-yl]benzenesulfonamides. Eur J Med Chem 45:3011–3018

4. Arcangeli A, Crociani O, Lastraioli E, Masi A, Pillozzi S, Becchetti A (2009) Targeting ion channels in cancer: a novel frontier in antineoplastic therapy. Curr Med Chem 16:66–93

5. Ashour FA, Rida SM, El-Hawash SAM, ElSemary MM, Badr MH (2011) Synthesis, anticancer, anti-HIV-1, and antimicrobial activity of some tricyclic triazino and triazolo[4,3-e]purine derivatives. Med Chem Res 21:1107–1119

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