Synthesis of amide warhead containing coumarin derivatives as potential pancreatic lipase inhibitors: in silico and in vitro evaluation for obesity treatment

Author:

Yadav Nisha,Paul Atish T.ORCID

Funder

DST-INSPIRE

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics

Reference36 articles.

1. World Health Organization (WHO) (2021) Fact Sheets, Obesity and overweight, https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight, accessed 31 Jan 2023

2. World Health Organization (WHO) (2022) Obesity causes cancer and is major determinant of disability and death, warns new WHO report, https://www.who.int/europe/news/item/03-05-2022-obesity-causes-cancer-and-is-major-determinant-of-disability-and-death--warns-new-who-report, accessed on 1 Feb 2023

3. Mukherjee M. Human digestive and metabolic lipases - A brief review. J Mol Catal B: Enzym. 2003;22:369–376. https://doi.org/10.1016/S1381-1177(03)00052-3

4. Egloff MP, Marguet F, Buono G, Verger R, Cambillau C, Van Tilbeurgh H. The 2.46 Å resolution structure of the pancreatic lipase-colipase complex inhibited by a C11 alkyl phosphonate. Biochem. J. 1995;34:2751–2762. https://doi.org/10.1021/bi00009a003

5. Hadvary P, Lengsfeld H, Wolfer H. Inhibition of pancreatic lipase in vitro by the covalent inhibitor tetrahydrolipstatin. Biochem J. 1988;256:357–361. https://doi.org/10.1042/bj2560357

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