Modifications to five-substituted 3,3-diethyl-4,5-dihydro-2(3H)-furanones en route to novel muscarinic receptor ligands

Author:

Bhandare Richie R.,Canney Daniel J.

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics

Reference24 articles.

1. Abrams P, Andersson KE, Buccafusco JJ, Chapple C, Groat WC, Fryer AD, Kay G, Laties A, Nathanson NM, Pasricha PJ, Wein AJ (2006) Muscarinic receptors: their distribution and function in body systems, and the implications for treating overactive bladder. Br J Pharmacol 148:565–578

2. Ahungena A, Canney DJ (1996) Synthesis and biological evaluation of aminomethyl/amidomethyl derivatives of an anticonvulsant γ-butyrolactone. Med Chem Res 6(9):618–634

3. Ahungena A, Gabriel JL, Canney DJ (2003) Synthesis and evaluation of 5-substituted derivatives of 4,5-dihydro-3,3-diethyl-2(3H)-furanone as subtype-selective muscarinic leads. Med Chem Res 12(9):481–511

4. Beers WH, Reich E (1970) Structure and activity of acetylcholine. Nature 228:917–922

5. Burstein ES, Spalding TA, Brann MR (1998) Structure/function relationships of a G-protein coupling pocket formed by the third intracellular loop of m5 muscarinic receptor. Biochemistry 37:4052–4058

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