Synthesis of 2-oxoquinoline derivatives as dual pim and mTORC protein kinase inhibitors
Author:
Funder
National Institute of General Medical Sciences
Publisher
Springer Science and Business Media LLC
Subject
Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics
Link
https://link.springer.com/content/pdf/10.1007/s00044-022-02904-z.pdf
Reference39 articles.
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2. Beharry Z, Mahajan S, Zemskova M, Lin YW, Tholanikunnel BG, Xia ZP, et al. The Pim protein kinases regulate energy metabolism and cell growth. Proc Natl Acad Sci USA. 2011;108:528–33.
3. Warfel NA, Kraft AS. PIM kinase (and Akt) biology and signaling in tumors. Pharmacol Therapeutics. 2015;151:41–9.
4. Son JH, Singh N, Luevano LA, Padi SKR, Okumura K, Olive V, et al. Mechanisms Behind Resistance to P13K Inhibitor Treatment Induced by the PIM Kinase. Mol Cancer Therapeutics. 2018;17:2710–21.
5. Amaravadi R, Thompson CB. The survival kinases Akt and Pim as potential pharmacological targets. J Clin Investig. 2005;115:2618–24.
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