Analogs of the κ opioid receptor antagonist arodyn cyclized by ring-closing metathesis retain κ opioid receptor affinity, selectivity and κ opioid receptor antagonism
Author:
Publisher
Springer Science and Business Media LLC
Subject
Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics
Link
https://link.springer.com/content/pdf/10.1007/s00044-021-02758-x.pdf
Reference38 articles.
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2. Carroll FI, Carlezon WA Jr. Development of kappa opioid receptor antagonists. J Med Chem. 2013;56:2178–95. https://doi.org/10.1021/jm301783x
3. Urbano M, Guerrero M, Rosen H, Roberts E. Antagonists of the kappa opioid receptor. Bioorg Med Chem Lett. 2014;24:2021–32. https://doi.org/10.1016/j.bmcl.2014.03.040
4. Carlezon WA Jr, Krystal AD. Kappa-opioid antagonists for psychiatric disorders: from bench to clinical trials. Depress Anxiety. 2016;33:895–906. https://doi.org/10.1002/da.22500
5. Helal MA, Habib ES, Chittiboyina AG. Selective kappa opioid antagonists for treatment of addiction, are we there yet? Eur J Med Chem. 2017;141:632–47. https://doi.org/10.1016/j.ejmech.2017.10.012
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1. A Bicyclic Analog of the Linear Peptide Arodyn Is a Potent and Selective Kappa Opioid Receptor Antagonist;Molecules;2024-06-29
2. Dynorphin 1-17 biotransformation peptides: properties, challenges and solutions for future therapeutics development;Future Medicinal Chemistry;2023-05
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