Synthesis of macrocyclic α-ketoamide as a selective and reversible immunoproteasome inhibitor
Author:
Funder
Center for Drug Design, University of Minnesota
Publisher
Springer Science and Business Media LLC
Subject
Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics
Link
http://link.springer.com/content/pdf/10.1007/s00044-020-02678-2.pdf
Reference43 articles.
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2. Finley D. Recognition and processing of ubiquitin-protein conjugates by the proteasome. Annu Rev Biochem. 2009;78:477–513. https://doi.org/10.1146/annurev.biochem.78.081507.101607
3. Ebstein F, Kloetzel PM, Kruger E, Seifert U. Emerging roles of immunoproteasomes beyond MHC class I antigen processing. Cell Mol Life Sci. 2012;69(15):2543–58. https://doi.org/10.1007/s00018-012-0938-0
4. Groettrup M, Khan S, Schwarz K, Schmidtke G. Interferon-gamma inducible exchanges of 20S proteasome active site subunits: why? Biochimie. 2001;83(3–4):367–72
5. Manasanch EE, Orlowski RZ. Proteasome inhibitors in cancer therapy. Nat Rev Clin Oncol. 2017;14(7):417–33. https://doi.org/10.1038/nrclinonc.2016.206
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