Design, synthesis and antitumor activity evaluation of 5-cyano-2,4,6-substituted pyrimidine derivatives containing acrylamide group-Reference-Cited by-同舟云学术

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Design, synthesis and antitumor activity evaluation of 5-cyano-2,4,6-substituted pyrimidine derivatives containing acrylamide group

Published:2023-07-07 Issue:10 Volume:32 Page:2116-2124
ISSN:1054-2523
Container-title:Medicinal Chemistry Research
language:en
Short-container-title:Med Chem Res

Author:

Yu Fuqiang,Chi Lingling,Wang Hao,Gao Chao,Dai Honglin,Liu Limin,Wang Zhengjie,Ke Yu,Liu Hongmin,Zhang Qiurong

Funder

National Natural Science Foundation of China

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics

Link

https://link.springer.com/content/pdf/10.1007/s00044-023-03099-7.pdf

Reference51 articles.

1. Shi Z-D, Pang K, Wu Z-X, Dong Y, Hao L, Qin J-X, et al. Tumor cell plasticity in targeted therapy-induced resistance: mechanisms and new strategies. Signal Transduct Target Ther. 2023;8:113. https://doi.org/10.1038/s41392-023-01383-x

2. Zhang L, Ye B, Chen Z, Chen Z-S. Progress in the studies on the molecular mechanisms associated with multidrug resistance in cancers. Acta Pharm Sin B. 2023;13:982–97. https://doi.org/10.1016/j.apsb.2022.10.002

3. Marinescu M. Biginelli reaction mediated synthesis of antimicrobial pyrimidine derivatives and their therapeutic properties. Molecules. 2021;26:6022 https://doi.org/10.3390/molecules26196022

4. Kappe CO. Recent advances in the Biginelli dihydropyrimidine synthesis. New tricks from an old dog. Acc Chem Res. 2000;33:879–88. https://doi.org/10.1021/ar000048h

5. Tan L, Wu C, Zhang J, Yu Q, Wang X, Zhang L, et al. Design, synthesis, and biological evaluation of heterocyclic-fused pyrimidine chemotypes guided by x-ray crystal structure with potential antitumor and anti-multidrug resistance efficacy targeting the colchicine binding site. J Medicinal Chem. 2023;66:3588–620. https://doi.org/10.1021/acs.jmedchem.2c02115

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