Computer simulation of the in vitro and in vivo anti-inflammatory activities of dihydropyrimidines acid derivatives through the inhibition of cyclooxygenase-2

Author:

Dhankar Raksha,Rahatgaonkar Anjali M.,Shukla Rakesh,Chorghade Mukund,Tiwari Ashutosh

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics

Reference38 articles.

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2. Argus Lab 4.0.1 docking software (2010). http://www.arguslab.coms . Accessed May 2011

3. Atwal KS, Rovnyak GC, O’Reilly BC, Schwartz J (1989) Substituted 1,4 dihydropyrimidines. Synthesis of selectively functionalised 2-hetero 1,4 dihydropyrimidines. J Org Chem 54:5898

4. Atwal KS, Swanson BN, Unger SE, Floyd DM, Morel S, Hedberg A, O’Reilly BC (1991) Dihydropyrimidine calcium channel blockers. 3.3-Carbamoyl-4-aryl-1,2,3,4 tetrahydro-6-methyl-5-pyrimidinecarboxylic acid esters as orally effective antihypertensive agents. J Med Chem 34:806–811

5. Bahekar SS, Shinde DB (2003) Synthesis and anti-inflammatory activity of some [2-amino-6-(4-substituted aryl)-4-(4-substituted phenyl)-1,6-dihydropyrimidine-5-yl] acetic acid derivatives. Acta Pharm 53:223–229

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