Development of LC-MS/MS methods affording identification and measurement of active metabolites in rat and dog plasma after oral dosing of a penta-ethyl ester prodrug of diethylenetriamine pentaacetic acid

Author:

Kagel John R.ORCID,Jay MichaelORCID,Zamboni William C.ORCID

Funder

National Institute of Allergy and Infectious Diseases

Publisher

Springer Science and Business Media LLC

Reference19 articles.

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2. FDA approves drugs to treat internal contamination from radioactive elements (2004) http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2004/ucm108339.htm. Accessed 30 May 2012.

3. U.S. Food and Drug Administration. Guidance for Industry. Internal Radioactive Contamination—Development of Decorporation Agents. 2006. http://www.fda.gov/CDER/guidance, Docket Number: FDA-2005-D-0025.

4. Stradling GN, Gray SA, Ellender M, Pearce M, Wilson I, Moody JC. et al. Removal of inhaled plutonium and americium from the rat by administration of ZnDTPA in drinking water. Hum Exp Toxicol. 1993;12:233–9. https://doi.org/10.1177/096032719301200306.

5. Spoor NL. The use of EDTA and DTPA for accelerating the removal of deposited transuranic elements from humans. 1977. Report NRPB-R59: National Radiological Protection Board, Harwell.

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