Childhood traumatic events and the dopaminergic theory of psychosis: A mini-review of studies investigating gene – environment interactions
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Published:2021-12-28
Issue:
Volume:
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ISSN:1046-1310
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Container-title:Current Psychology
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language:en
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Short-container-title:Curr Psychol
Author:
Frydecka Dorota, Hamza Eid AboORCID, Helal Ahmed, Moustafa Ahmed A.
Abstract
Abstract
There is great body of evidence showing a relationship between childhood adversity and psychosis onset. Genetic factors moderate the association between childhood adversity and psychosis risk potentially by influencing biological and/or psychological reaction following exposure to adversity. In this review, we discuss studies identifying the specific genetic variants known to affect dopamine levels involved in this interaction. Our review shows that the catechol-O-methyltransferase (COMT), dopamine D2 receptor (DRD2), AKT1 gene play a key role in mediating the relationship between childhood adversity and development of psychosis. We have also found conflicting findings on the impact of dopamine genes on the relationship between childhood adversity and development of psychosis, suggesting that other genetic and environmental factors should be taken into account. We here discuss the implications of our findings and future directions.
Funder
National Science Centre
Publisher
Springer Science and Business Media LLC
Subject
General Psychology
Reference118 articles.
1. Aas, M., Andreassen, O. A., Aminoff, S. R., Faerden, A., Romm, K. L., Nesvag, R., ..., Melle, I. (2016). A history of childhood trauma is associated with slower improvement rates: Findings from a one-year follow-up study of patients with a first-episode psychosis. BMC Psychiatry, 16, 126.https://doi.org/10.1186/s12888-016-0827-4 2. Ahmadi, L., Kazemi Nezhad, S. R., Behbahani, P., Khajeddin, N., & Pourmehdi-Boroujeni, M. (2018). Genetic Variations of DAOA (rs947267 and rs3918342) and COMT Genes (rs165599 and rs4680) in Schizophrenia and Bipolar I Disorder. Basic Clin Neurosci, 9(6), 429–438. https://doi.org/10.32598/bcn.9.6.429 3. Akil, M., Kolachana, B. S., Rothmond, D. A., Hyde, T. M., Weinberger, D. R., & Kleinman, J. E. (2003). Catechol-O-methyltransferase genotype and dopamine regulation in the human brain. Journal of Neuroscience, 23(6), 2008–2013. 4. Alexander, N., Osinsky, R., Mueller, E., Schmitz, A., Guenthert, S., Kuepper, Y., & Hennig, J. (2011). Genetic variants within the dopaminergic system interact to modulate endocrine stress reactivity and recovery. Behavioural Brain Research, 216(1), 53–58. https://doi.org/10.1016/j.bbr.2010.07.003 5. Bajestan, S. N., Sabouri, A. H., Nakamura, M., Takashima, H., Keikhaee, M. R., Behdani, F., ..., Osame, M. (2006). Association of AKT1 haplotype with the risk of schizophrenia in Iranian population. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 141B(4), 383–386. doi:https://doi.org/10.1002/ajmg.b.30291
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