Influence of Age and Obesity on 5α-Reductase 2 Gene Expression
Author:
Publisher
Springer Science and Business Media LLC
Subject
Molecular Biology,Biochemistry
Link
http://link.springer.com/content/pdf/10.1007/s11884-016-0361-8.pdf
Reference23 articles.
1. Parsons JK. Modifiable risk factors for benign prostatic hyperplasia and lower urinary tract symptoms: new approaches to old problems. J Urol. 2007;178:395–401. Discusses the BPH etiology, other than sex-steroid hormones; identification of the new BPH risk factors, such as obesity and metabolic syndrome. This study suggests the potential therapeutic effect of the physical activity and diet in-between medical and surgical therapies in BPH- risk patients.
2. Parsons JK, Sarma AV, McVary K, Weiss JT. Obesity and benign prostatic h: clinical connections, emerging etiological paradigms and future directions. J Urol. 2013;189:S102–6. Summarizes evidence regarding the association between obesity and metabolic syndrome with increased prostate volume, BPH and LUTS, as well as the contribution of increased adiposity to the prostate growth.
3. Wang S, Mao Q, Lin Y, Wu X, Wang X, Zheng X, et al. Body mass index and risk of BPH: a meta-analysis. Prostate Cancer Prostatic Dis. 2012;15:265–72. This review of 19 studies suggests the strong association of BMI with the increased risk of BPH. The review also discusses endocrine changes seen in the elderly and the obese as well as the role of inflammation and oxidative stress in the etiology of BPH.
4. Kaplan S, O’Neill EA, Lowe R, Hanson M, Meehan AG. Prevalence of low testosterone in aging men with benign prostatic hyperplasia: data from Proscar Long-term Efficacy and Safety Study (PLESS). Aging Male. 2013;16(2):48–51. Analysis of baseline data from 299 patients, participating in the PLESS study, which demonstrates the impact of higher BMI on testosterone levels in patients with symptomatic BPH. Discusses the inverse relationship between testosterone and BMI as well as the role of adipose tissue in aromatization.
5. Kaplan S, Lee JY, O’Neill EA, Meehan AG, Kusek JW. Prevalence of low testosterone and its relationship body mass index in older men with lower urinary tract symptoms associated with benign prostatic hyperplasia. Aging Male. 2013;16(4):169–72.
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