Author:
Harriehausen Isabel,Wrzosek Katarzyna,Lorenz Heike,Seidel-Morgenstern Andreas
Abstract
AbstractEnantioselective chromatography is nowadays a reliable tool for single enantiomer production from a racemate. The recovery of the distomer by racemization and recycling is a promising method to tackle the 50% yield constraint and to increase the productivity. In this paper three process configurations are compared. The production of enantiopure mandelic acid and methionine enantiomers exploiting different enzymes for racemization are evaluated as part of different chromatographic process configurations. First, the benefits of conventional simulated moving bed (SMB) chromatography in contrast to a single column batch separation unit are assessed in integrated configurations. Then, a concept of coupling the racemization with a simpler three-zone SMB unit, where one regeneration zone is removed, is evaluated.
Publisher
Springer Science and Business Media LLC
Subject
Surfaces and Interfaces,General Chemical Engineering,General Chemistry
Reference27 articles.
1. Bechtold, M., Makart, S., Heinemann, M., Panke, S.: Integrated operation of continuous chromatography and biotransformations for the generic high yield production of fine chemicals. J. Biotechnol. 124(1), 146–162 (2006)
2. Broughton, D.B., Gerhold, C.G.: Continuous sorption process employing fixed bed of sorbent and moving inlets and outlets. US Patent 2,985,589 (1961)
3. Femmer, C., Bechtold, M., Roberts, T.M., Panke, S.: Exploiting racemases. Appl. Microbiol. Biotechnol. 100(17), 7423–7436 (2016)
4. Franco, P., Senso, A., Oliveros, L., Minguillón, C.: Covalently bonded polysaccharide derivatives as chiral stationary phases in high-performance liquid chromatography. J. Chromatogr. A 906(1–2), 155–170 (2001)
5. Francotte, E.R.: Enantioselective chromatography as a powerful alternative for the preparation of drug enantiomers. J. Chromatogr. A 906(1–2), 379–397 (2001)
Cited by
10 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献