Incoherent dose-escalation in phase I trials using the escalation with overdose control approach

Author:

Wheeler Graham M.ORCID

Funder

Medical Research Council (GB)

Publisher

Springer Science and Business Media LLC

Subject

Statistics, Probability and Uncertainty,Statistics and Probability

Reference22 articles.

1. Babb JS, Rogatko A (2001) Patient specific dosing in a cancer phase I clinical trial. Stat Med 20:2079–2090. doi: 10.1002/sim.848

2. Babb JS, Rogatko A (2004) Bayesian methods for phase I cancer clinical trials. In: Geller NL (ed) Advances in clinical trial biostatistics. Marcel Dekker, New York, pp 1–40

3. Babb JS, Rogatko A, Zacks S (1998) Cancer phase I clinical trials: efficient dose escalation with overdose control. Stat Med 17(10):1103–1120

4. Bartroff J, Lai TL (2011) Incorporating individual and collective ethics into phase I cancer trial designs. Biometrics 67(2):596–603. doi: 10.1111/j.1541-0420.2010.01471.x

5. Carter SK (1973) Study design principles for the clinical evaluation of new drugs as developed by the chemotherapy programme of the National Cancer Institute. In: Staquet M (ed) The design of clinical trials in cancer therapy. Editions Scientifique Europe, pp 242–289

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