Effects of KT-362, a sarcolemmal and intracellular calcium antagonist, on calcium transients of cultured neonatal rat ventricular cells: A comparison with gallopamil and ryanodine

Author:

Tatsukawa Youichi,Arita Makoto

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cardiology and Cardiovascular Medicine,Pharmacology,General Medicine

Reference31 articles.

1. Wakabayashi, S, Mochizuki, J, Tomiyama, A, Shibata, S. Evaluation of cardiovascular effects and antiarrhythmic activity of KT-362 (5-[3-([2-(3,4-dimethoxyphenyl).-3thyl] amino)-1-oxopopyl]-2,3,4,5-tetrahydro-1,5-benzothiazepine fumarate, KT), a new intracellular Ca2+ inhibitor. Fed Proc 1986;45:803.

2. Farber, NE, Gross, GJ. Cardioprotective effects of a new vascular intracellular calcium antagonist, KT-362, in the stunned myocardium. J Pharmacol Exp Ther 1989;248:39?43.

3. Hester, R, Shibata, S. KT-362 related effects on intracellular calcium release and associated clinical potential, arrhythmias, myocardial ischemia and hypertension. Cardiovasc Drugs Ther 1990;4:1345?1354.

4. Sakata, K, Karaki, H. Effects of a novel smooth muscle relaxant, KT-362, on contraction and cytosolic Ca2+ level in the rat aorta. Br J Pharmacol 1991;102:174?178.

5. Shibata, S, Wakabayashi, S, Satake, N, Hester, RK, Ueda, S, Tomiyana, A. Mode of vasorelaxing action of 5 5-[3-([2-(3,4-dimethoxyphenyl)-ethyl]amino)-1-oxopropyl]-2,3,4,5-tetrahydro-1,5-benzothiazepine fumarate (KT-362), a new intracellular calcium antagonist. J Pharmacol Exp Ther 1987; 240:16?22.

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