Affiliation:
1. Department of Laboratory Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health, 840 Murodo-Cho, Izumi, Osaka 594-1101, Japan
2. Department of Neonatology, Osaka Medical Center and Research Institute for Maternal and Child Health, 840 Murodo-Cho, Izumi, Osaka 594-1101, Japan
3. Department of Clinical Pathology, Osaka Medical College, Takatsuki, 2–7 Daigaku Machi, Osaka 569-0801, Japan
Abstract
The serum concentration of inflammation-associated proteins and several complement components in the cord blood of 215 newborns with and without chorioamnionitis (CAM), who were delivered between 17 and 42 weeks of gestation, were measured. We investigated the relationship of levels of serum proteins to acute, subacute, and chronic CAM, and to subacute necrotizing funisitis (SNF). Complement components C3d, C3, and C4 levels increased in subacute CAM ( P = 0.0002, P = 0.0007, P = 0.0029, respectively), whereas factor B increased in each type of CAM ( P = 0.0001, P = 0.0009, P = 0.0004, respectively). Among the immunoglobulins, IgG levels were unrelated to the presence or type of CAM, IgM levels increased in subacute CAM ( P < 0.0001), and IgA levels increased in chronic CAM ( P < 0.0001). Among the acute phase reactants (APR), haptoglobin and C-reactive protein (CRP) levels increased in acute ( P < 0.0001, P = 0.0022, respectively) and chronic CAM ( P = 0.0035, P = 0.0345, respectively), whereas orosomucoid levels increased in chronic CAM ( P = 0.0003). IL-6 levels increased in acute ( P = 0.0011) and subacute ( P = 0.0475) CAM. C3d ( P = 0.0063), C3 ( P = 0.0289), C4 ( P = 0.0491), and IgM ( P < 0.0001) levels were increased in SNF. These findings suggest that the histologic distinction of acute, subacute, and chronic CAM is a useful indicator of the inflammatory mediator status of the infants. The infants with SNF may have ended their initial active inflammatory states, but they still have subacute immune activation.
Subject
General Medicine,Pathology and Forensic Medicine,Pediatrics, Perinatology, and Child Health
Cited by
25 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Intrauterine
Ureaplasma
is associated with small airway obstruction in extremely preterm infants;Pediatric Pulmonology;2022-08-17
2. Neuroprotective Potential of Dendritic Cells and Sirtuins in Multiple Sclerosis;International Journal of Molecular Sciences;2022-04-14
3. Infectious Diseases;Benirschke's Pathology of the Human Placenta;2021-12-08
4. Placental Membranes;Atlas of Placental Pathology;2021-08
5. The Umbilical Cord;Atlas of Placental Pathology;2021-08