Affiliation:
1. Department of Pathology and Laboratory Medicine, Wayne State University School of Medicine, 540 E. Canfield, Detroit, MI 48201, USA
Abstract
The aim of this review is to introduce the reader to the main ECM constituents and to some of their roles in development. The main functions of the ECM during embryogenesis are the production, promotion, and regulation of normal tissue structure. Among the ECM components, LMs have been the most extensively studied in relation to embryo-genesis. Skin and skeletal muscle disorders have been shown to be caused by LM alterations. Additional experiments, e.g., with knockout mice, will help enormously to elucidate the functional significance of many ECM constituents and their involvement in development and disease.
Subject
General Medicine,Pathology and Forensic Medicine,Pediatrics, Perinatology, and Child Health
Cited by
17 articles.
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