Characterization of lidocaine metabolism by rat nasal microsomes: implications for nasal drug delivery

Author:

Deshpande V. S.,Genter M. B.,Jung C.,Desai P. B.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology

Reference27 articles.

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2. Hermansson J., Glaumann H., Karlen B., Von Bahr C. (1980): Metabolism of lidocaine in human liver in vitro. Acta Pharmacol. Toxicol., 47, 49–52.

3. Imaoka S., Enomoto K., Oda Y. et al. (1990): Lidocaine metabolism by human cytochrome P-450s purified from hepatic microsomes: comparison of those with rat hepatic cytochrome P-450s. J. Pharmacol. Exp. Ther., 255, 1385–1391.

4. Parker RJ., Collins J.M., Strong J.M. (1996): Identification of 2,6-xylidide as a major lidocaine metabolite in human liver slices. Drug Metab. Dispos., 24, 1167–1173.

5. Imaoka S., Yamada T., Hiroi T. et. al. (1996): Multiple forms of human P450 expressed inSaccharomyces cerevisiae: systemic characterization and comparison with those of the rat. Biochem. Pharmacol., 51: 1041–1050.

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