Δ2-Valproate biotransformation using human liver microsomal fractions

Author:

Fabre Gérard,Briot Christophe,Marti Eric,Montseny Jean -Pierre,Bourrié Martine,Massé Danielle,Berger Yves,Cano Jean -Paul

Publisher

Springer Science and Business Media LLC

Subject

Pharmaceutical Science,Pharmacology (medical),Pharmacology

Reference23 articles.

1. Bourgeouis BFD. Valproate; clinical use. In: Levy RH, Dreyfuss FE, Mattson RH, Meldrum BS, Penry JK, eds. Antiepileptic drugs. 3rd ed. New York: Raven Press, 1989:633–42.

2. Granneman GR, Wang SI, Machinist JM, Kesterson JW. Aspects of the metabolism of valproic acid. Xenobiotica 1984;14:375–87.

3. Nau H. Transfer of valproic acid and its main active unsaturated metabolite to the gestational tissue: correlation with neural tube defect formation in the mouse. Teratology 1986;33:21–7.

4. Lewandowski C, Klug S, Nau H, Neubert D. Pharmacokinetic aspects of drug effectsin vitro: effects of serum protein binding on concentration and teratogenicity of valproic acid and 2-en valproic acid. Arch Toxicol 1984;58:239–42.

5. Loscher W, Nau H. Comparative transfer of valproic acid and of an active metabolite into brain and liver: possible pharmacological and toxicological consequences. Arch Int Pharmacodyn Ther 1984;279:199–202.

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