Density-Functional Theory Investigations of Enzyme-substrate Interactions

Author:

Carloni Paolo,Alber Frank

Publisher

Springer Netherlands

Reference42 articles.

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2. Kohn, W. and Sham, L.J., Self-consistent equations including exchange and correlation effects, Phys. Rev., 140 (1965) A1133–A1138.

3. For a detailed discussion of the DFT methods and applications in biochemistry, the reader is referred to Andreoni, W., Density-functional theory and molecular dynamics: A new perspective for simulations of biological systems, this volume.

4. See, e.g. (a) Li, Yan and Evans, J.N.S., The hard-soft acid-base principlein enzymatic catalysis: Dual reactivity of phosphoenolpyruvate, Proc. Natl. Acad. Sci., 93 (1996) 4612–4616 (b) Hütter, J., Carloni, P. and Parrinello, M. Non-empirical calculationson a hydrated RNA duplex, J. Am. Chem. Soc., 18 (1996) 8710—8712; (c) Carloni, P. and Andreoni, W., Platinum-modifiednucleobasepairs in the solid state: A theoretical study, J. Phys. Chem., 100 (1996) 17797–17800; (d) Bernardi, F., Bottoni, A., Casadio, R., Fariselli, P. and Rigo, A., Ab initio study of the dioxygen bindingsite of hemocyanin: A comparisonbetweenCASSCF, CASPT2, and DFT approaches., Int. J. Quant. Chem., 58 (1996) 109–119; (e) Sagnella, D.E., Laasonen, K. and Klein, M.L., Ab initio molecular dynamics study of protontransfer in a polyglycine analogof the ion channel gramicidin A., Biophys. J., 71 (1996) 1172–1178; (f) Oldziej, S.and Ciarkowski, J., Mechanism of action of aspartic proteinases: Application of transition-state analogue theory., J. Cornput.-Aided Mol. Design, 10 (1996) 583–588; and (g) Bajorath, J., Kraut, J., Li, Z.Q., Kitsoon, D.H. and Hagler, A.T., Theoretical studies on the dihydrofolatereductase mechanism: Electronic polarizationof bound substrates, Proc. Natl. Acad. Sci. USA, 88 (1991) 6423–6426.

5. York, D.M., Lee, T.S. and Yang, W., Quantum mechanical study of aqueous polarization effects on biological macromolecules, J. Am. Chem. Soc., 118 (1996) 10940–10941, and references therein.

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