Abstract
AbstractThe "watch and wait" (W&W) strategy has been widely used in rectal cancer patients who have achieved clinical complete response (cCR) after neoadjuvant chemoradiotherapy (nCRT), which can save them from surgery and improve their quality of life. However, this strategy also has many unsolved practical problems, including the improvement of cCR/pCR rate, the search for efficient predictors, the standard follow-up and the methods of rescue surgery, etc. Larger sample size and more standardized clinical trials are still needed to obtain credible evidence. Therefore, we must rationally view the cCR after nCRT for middle and low rectal cancer, understand the risk of W&W strategy, and make a reasonable choice. It is particularly important to emphasize that we should actively carry out prospective multi-center clinical trials to produce high-level evidence suitable for Chinese characteristics, so that more rectal cancer patients can benefit from nCRT.
Funder
Capital’s Funds for Health Improvement and Research
National Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC
Cited by
3 articles.
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