Abstract
Abstract
Conventional skin and blood sampling techniques for disease diagnosis, though effective, are often highly invasive and some even suffer from variations in analysis. With the improvements in molecular detection, the amount of starting sample quantity needed has significantly reduced in some diagnostic procedures, and this has led to an increased interest in microsampling techniques for disease biomarker detection. The miniaturization of sampling platforms driven by microsampling has the potential to shift disease diagnosis and monitoring closer to the point of care. The faster turnaround time for actionable results has improved patient care. The variations in sample quantification and analysis remain a challenge in the microsampling field. The future of microsampling looks promising. Emerging techniques are being clinically tested and monitored by regulatory bodies. This process is leading to safer and more reliable diagnostic platforms. This review discusses the advantages and disadvantages of current skin and blood microsampling techniques.
Funder
National Health and Medical Research
University of Queensland
Publisher
Springer Science and Business Media LLC
Subject
Molecular Biology,Biomedical Engineering
Reference115 articles.
1. N. Ackerman et al., Glucose monitoring via reverse iontophoresis. American Chemical Society, Polymer Preprints, Division of Polym. Chem 40, 303–304 (1999)
2. P.C. Alguire, B.M. Mathes, Skin biopsy techniques for the internist. J. Gen. Intern. Med. 13, 46–54 (1998)
3. E. Andrews et al., Concurrent human papillomavirus–associated tonsillar carcinoma in 2 couples. J. Infect. Dis. 200, 882–887 (2009)
4. A. Arima et al., Selective detections of single-viruses using solid-state nanopores. Sci. Rep. 8, 16305 (2018)
5. S.E. Asha et al., Impact from point-of-care devices on emergency department patient processing times compared with central laboratory testing of blood samples: A randomised controlled trial and cost-effectiveness analysis. Emerg. Med. J. 31, 714–719 (2014)
Cited by
86 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献