Essential Metals in Cryptococcus neoformans: Acquisition and Regulation
Author:
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases
Link
http://link.springer.com/content/pdf/10.1007/s12281-014-0180-3.pdf
Reference97 articles.
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4. Wagner D, Maser J, Lai B, Cai Z, Barry III CE, Honer Zu Bentrup K, et al. Elemental analysis of Mycobacterium avium-, Mycobacterium tuberculosis-, and Mycobacterium smegmatis-containing phagosomes indicates pathogen-induced microenvironments within the host cell's endosomal system. J Immunol. 2005;174(3):1491–500.
5. Wolschendorf F, Ackart D, Shrestha TB, Hascall-Dove L, Nolan S, Lamichhane G, et al. Copper resistance is essential for virulence of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2011;108(4):1621–6. A mutant of M. tuberculosis lacking an outer membrane channel accumulates more copper than the wild-type strain and also shows greater susceptibility to copper toxicity. The mutant showed reduced bacterial burden in the lungs and lymph nodes of guinea pigs, in support of an important role for copper in host resistance.
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