Memory deficits in a juvenile rat model of type 1 diabetes are due to excess 11β-HSD1 activity, which is upregulated by high glucose concentrations rather than insulin deficiency
Author:
Funder
Société Française d'Endocrinologie et Diabétologie Pédiatrique
Publisher
Springer Science and Business Media LLC
Subject
Endocrinology, Diabetes and Metabolism,Internal Medicine
Link
https://link.springer.com/content/pdf/10.1007/s00125-023-05942-3.pdf
Reference43 articles.
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2. Shalimova A, Graff B, Gąsecki D et al (2019) Cognitive dysfunction in type 1 diabetes mellitus. J Clin Endocrinol Metab 104(6):2239–2249. https://doi.org/10.1210/jc.2018-01315
3. McCrimmon RJ, Ryan CM, Frier BM (2012) Diabetes and cognitive dysfunction. Lancet 379(9833):2291–2299. https://doi.org/10.1016/S0140-6736(12)60360-2
4. Creo AL, Cortes TM, Jo HJ et al (2021) Brain functions and cognition on transient insulin deprivation in type 1 diabetes. JCI Insight 6(5):e144014. https://doi.org/10.1172/jci.insight.144014
5. Silver I, Erecinska M (1994) Extracellular glucose concentration in mammalian brain: continuous monitoring of changes during increased neuronal activity and upon limitation in oxygen supply in normo-, hypo-, and hyperglycemic animals. J Neurosci 14(8):5068–5076. https://doi.org/10.1523/JNEUROSCI.14-08-05068.1994
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