Abstract
AbstractThe discovery of insulin in 1921 has been one of greatest scientific achievements of the 20th century. Since then, the availability of insulin has shifted the focus of diabetes treatment from trying to keep patients alive to saving and improving the life of millions. Throughout this time, basic and clinical research has advanced our understanding of insulin synthesis and action, both in healthy and pathological conditions. Yet, multiple aspects of insulin production remain unknown. In this review, we focus on the most recent findings on insulin synthesis, highlighting their relevance in diabetes.
Funder
French National Agency for Research (ANR) and the German Research Foundation
EU-IMI
BMBF funded German Centre for Diabetes Research
German-Israeli Foundation for Scientific Research and Development
Publisher
Springer Science and Business Media LLC
Subject
Endocrinology, Diabetes and Metabolism,Internal Medicine
Reference89 articles.
1. Weiss M, Steiner DF, Philipson LH (2014) Insulin biosynthesis, secretion, structure, and structure-activity relationships. In: Feingold K, Anawalt B, Boyce A et al (eds) Endotext [Internet]. MDText.com, Inc., South Dartmouth (MA)
2. Csajbók ÉA, Tamás G (2016) Cerebral cortex: a target and source of insulin? Diabetologia 2016 598 59(8):1609–1615. https://doi.org/10.1007/s00125-016-3996-2
3. Suckale J, Solimena M (2010) The insulin secretory granule as a signaling hub. Trends Endocrinol Metab 21(10):599–609. https://doi.org/10.1016/J.TEM.2010.06.003
4. Arvan P, Halban PA (2004) Sorting ourselves out: seeking consensus on trafficking in the beta-cell. Traffic 5(1):53–61. https://doi.org/10.1111/j.1600-0854.2004.00152.x
5. Lee Y, Kim J, Park K, Lee M-S (2019) β-Cell autophagy: mechanism and role in β-cell dysfunction. Mol Metab 27:S92–S103. https://doi.org/10.1016/j.molmet.2019.06.014
Cited by
56 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献