TCF7L2 rs7903146 impairs islet function and morphology in non-diabetic individuals-Reference-Cited by-同舟云学术

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TCF7L2 rs7903146 impairs islet function and morphology in non-diabetic individuals

Published:2012-08-22 Issue:10 Volume:55 Page:2677-2681
ISSN:0012-186X
Container-title:Diabetologia
language:en
Short-container-title:Diabetologia

Author:

Le Bacquer O.,Kerr-Conte J.,Gargani S.,Delalleau N.,Huyvaert M.,Gmyr V.,Froguel P.,Neve B.,Pattou F.

Publisher

Springer Science and Business Media LLC

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

http://link.springer.com/content/pdf/10.1007/s00125-012-2660-8.pdf

Reference12 articles.

1. Schafer SA, Machicao F, Fritsche A, Haring HU, Kantartzis K (2011) New type 2 diabetes risk genes provide new insights in insulin secretion mechanisms. Diabetes Res Clin Pract 93(Suppl 1):S9–S24

2. Le Bacquer O, Shu L, Marchand M et al (2011) TCF7L2 splice variants have distinct effects on beta cell turnover and function. Hum Mol Genet 20:1906–1915

3. Shu L, Matveyenko AV, Kerr-Conte J, Cho JH, McIntosh CH, Maedler K (2009) Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta cell function. Hum Mol Genet 18:2388–2399

4. Rosengren AH, Braun M, Mahdi T et al (2012) Reduced insulin exocytosis in human pancreatic beta cells with gene variants linked to type 2 diabetes. Diabetes 61:1726–1733

5. Vantyghem MC, Kerr-Conte J, Arnalsteen L et al (2009) Primary graft function, metabolic control, and graft survival after islet transplantation. Diabetes Care 32:1473–1478

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