A novel dual PPAR-γ agonist/sEH inhibitor treats diabetic complications in a rat model of type 2 diabetes-Reference-Cited by-同舟云学术

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A novel dual PPAR-γ agonist/sEH inhibitor treats diabetic complications in a rat model of type 2 diabetes

Published:2018-07-21 Issue:10 Volume:61 Page:2235-2246
ISSN:0012-186X
Container-title:Diabetologia
language:en
Short-container-title:Diabetologia

Author:

Hye Khan Md Abdul^ORCID,Kolb Lauren,Skibba Melissa,Hartmann Markus,Blöcher René,Proschak Ewgenij,Imig John D.

Funder

Forschungsgemeinschaft

Dr. Ralph and Marian Falk Medical Research Trust Bank of America, N.A., Trustee grant

German Cancer Consortium

Else-Kröner-Fresenius Foundation graduate college for Translational Research Innovation

NIH Blueprint for Neuroscience Research

Publisher

Springer Science and Business Media LLC

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

http://link.springer.com/article/10.1007/s00125-018-4685-0/fulltext.html

Reference63 articles.

1. Potenza MV, Mechanick JI (2009) The metabolic syndrome: definition, global impact, and pathophysiology. Nutr Clin Pract 24:560–577

2. Isomaa B, Almgren P, Tuomi T et al (2001) Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care 24:683–689

3. Grundy SM (2006) Drug therapy of the metabolic syndrome: minimizing the emerging crisis in polypharmacy. Nat Rev Drug Discov 5:295–309

4. Imig JD (2010) Targeting epoxides for organ damage in hypertension. J Cardiovasc Pharmacol 56:329–335

5. Luria A, Bettaieb A, Xi Y et al (2011) Soluble epoxide hydrolase deficiency alters pancreatic islet size and improves glucose homeostasis in a model of insulin resistance. Proc Natl Acad Sci U S A 108:9038–9043

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