Long-term c-Kit overexpression in beta cells compromises their function in ageing mice
Author:
Funder
Institute of Nutrition, Metabolism and Diabetes
Publisher
Springer Science and Business Media LLC
Subject
Endocrinology, Diabetes and Metabolism,Internal Medicine
Link
http://link.springer.com/content/pdf/10.1007/s00125-019-4890-5.pdf
Reference49 articles.
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2. Peters K, Panienka R, Li J, Klöppel G, Wang R (2005) Expression of stem cell markers and transcription factors during the remodeling of the rat pancreas after duct ligation. Virchows Arch 446(1):56–63. https://doi.org/10.1007/s00428-004-1145-7
3. Li J, Quirt J, Do HQ et al (2007) Expression of c-Kit receptor tyrosine kinase and effect on beta-cell development in the human fetal pancreas. Am J Physiol Endocrinol Metab 293(2):E475–E483. https://doi.org/10.1152/ajpendo.00172.2007
4. Feng ZC, Li J, Turco BA, Riopel M, Yee SP, Wang R (2012) Critical role of c-Kit in beta cell function: increased insulin secretion and protection against diabetes in a mouse model. Diabetologia 55(8):2214–2225. https://doi.org/10.1007/s00125-012-2566-5
5. Feng ZC, Donnelly L, Li J, Krishnamurthy M, Riopel M, Wang R (2012) Inhibition of Gsk3β activity improves β-cell function in c-Kit Wv/+ male mice. Lab Investig 92(4):543–555. https://doi.org/10.1038/labinvest.2011.200
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