An adult-based insulin resistance genetic risk score associates with insulin resistance, metabolic traits and altered fat distribution in Danish children and adolescents who are overweight or obese

Author:

Graae Anne-Sofie,Hollensted Mette,Kloppenborg Julie T.,Mahendran Yuvaraj,Schnurr Theresia M.,Appel Emil Vincent R.,Rask Johanne,Nielsen Tenna R. H.,Johansen Mia Ø.,Linneberg Allan,Jørgensen Marit E.,Grarup Niels,Kadarmideen Haja N.,Holst Birgitte,Pedersen Oluf,Holm Jens-Christian,Hansen Torben

Funder

Innovation Fund Denmark

The Danish Diabetes Academy

The Region Zealand Health Scientific Research Foundation

Publisher

Springer Science and Business Media LLC

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Reference34 articles.

1. International Diabetes Federation (2006) The IDF consensus worldwide definition of the Metabolic Syndrome. Available from http://www.idf.org/e-library/consensus-statements/60-idfconsensus-worldwide-definitionof-the-metabolic-syndrome . Accessed 17 Sep 2017

2. Roberts CK, Hevener AL, Bernard RJ (2014) Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training. Compr Physiol 3:1–58

3. Sinha R, Fisch G, Teague B et al (2002) Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med 346:802–810

4. Kloppenborg JT, Fonvig CE, Nielsen TRH et al (2017) Impaired fasting glucose and the metabolic profile in Danish children and adolescents with normal weight, overweight, or obesity. Pediatr Diabetes 1–10

5. Zimmermann E, Bjerregaard LG, Gamborg M et al (2017) Childhood body mass index and development of type 2 diabetes throughout adult life—A large-scale danish cohort study. Obesity 25:965–971

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