Impaired beta cell glucose sensitivity rather than inadequate compensation for insulin resistance is the dominant defect in glucose intolerance

Author:

Mari A., ,Tura A.,Natali A.,Laville M.,Laakso M.,Gabriel R.,Beck-Nielsen H.,Ferrannini E.

Publisher

Springer Science and Business Media LLC

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Reference24 articles.

1. Kahn SE, Porte D Jr (2003) The pathophysiology and genetics of type 2 diabetes mellitus. In: Porte D Jr, Sherwin R, Baron A (eds) Ellenberg and Rifkin’s diabetes mellitus, 6th edn. McGraw-Hill, New York, pp 331–365

2. DeFronzo RA, Mandarino L, Ferrannini E (2004) Metabolic and molecular pathogenesis of type 2 diabetes mellitus. In: DeFronzo RA, Ferrannini E, Keen H, Zimmet P (eds) International textbook of diabetes mellitus, 3rd edn. Wiley, Chichester

3. Bergman RN, Ader M, Huecking K, van Citters G (2002) Accurate assessment of beta-cell function: the hyperbolic correction. Diabetes 51(Suppl 1):S212–S220

4. Kahn SE (2003) The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia 46:3–19

5. Stumvoll M, Tataranni PA, Stefan N, Vozarova B, Bogardus C (2003) Glucose allostasis. Diabetes 52:903–909

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