Insulin signalling in hepatocytes of humans with type 2 diabetes: excessive production and activity of protein kinase C-ι (PKC-ι) and dependent processes and reversal by PKC-ι inhibitors-Reference-Cited by-同舟云学术

Insulin signalling in hepatocytes of humans with type 2 diabetes: excessive production and activity of protein kinase C-ι (PKC-ι) and dependent processes and reversal by PKC-ι inhibitors

Published:2012-02-15 Issue:5 Volume:55 Page:1446-1457
ISSN:0012-186X
Container-title:Diabetologia
language:en
Short-container-title:Diabetologia

Author:

Sajan M. P.,Farese R. V.

Publisher

Springer Science and Business Media LLC

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

http://link.springer.com/content/pdf/10.1007/s00125-012-2477-5.pdf

Reference21 articles.

1. Standaert ML, Sajan MP, Miura A et al (2004) Insulin-induced activation of atypical protein kinase C, but not protein kinase B, is maintained in diabetic ob/ob and Goto–Kakizaki liver. Contrasting insulin signaling patterns in liver versus muscle define phenotypes of type 2 diabetic and high fat-induced insulin-resistant states. J Biol Chem 279:24929–24934

2. Sajan MP, Standaert ML, Nimal S et al (2009) Critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFκB in obesity. J Lipid Res 50:1133–1145

3. Sajan MP, Standaert ML, Rivas J et al (2009) Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFkappaB) in liver of rodents used as model of diabetes, and relationships to hyperlipidaemia and insulin resistance. Diabetologia 52:1197–1207

4. Valverde AM, Burks DJ, Fabregat I et al (2003) Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes. Diabetes 52:2239–2248

5. Ueki K, Yamauchi T, Tamemoto H et al (2000) Restored insulin-sensitivity in IRS-1-deficient mice treated by adenovirus-mediated gene therapy. J Clin Invest 105:1437–1445

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