Hepatic p38α MAPK controls gluconeogenesis via FOXO1 phosphorylation at S273 during glucagon signalling in mice-Reference-Cited by-同舟云学术

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Hepatic p38α MAPK controls gluconeogenesis via FOXO1 phosphorylation at S273 during glucagon signalling in mice

Published:2023-05-19 Issue:7 Volume:66 Page:1322-1339
ISSN:0012-186X
Container-title:Diabetologia
language:en
Short-container-title:Diabetologia

Author:

Yang Wanbao,Liao Wang,Li Xiaopeng,Ai Weiqi,Pan Quan,Shen Zheng,Jiang Wen,Guo Shaodong

Funder

American Diabetes Association Career Development Award

USDA National Institute of Food and Agriculture

National Institutes of Health

Publisher

Springer Science and Business Media LLC

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://link.springer.com/content/pdf/10.1007/s00125-023-05916-5.pdf

Reference43 articles.

1. D’alessio D (2011) The role of dysregulated glucagon secretion in type 2 diabetes. Diabetes Obes Metab 13:126–132. https://doi.org/10.1111/j.1463-1326.2011.01449.x

2. Magnusson I, Rothman D, Katz L, Shulman R, Shulman G (1992) Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study. J Clin Investig 90(4):1323–1327. https://doi.org/10.1172/JCI115997

3. Unger RH, Cherrington AD (2012) Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover. J Clin Investig 122(1):4–12. https://doi.org/10.1172/JCI60016

4. Haeusler RA, Kaestner KH, Accili DJJoBC (2010) FoxOs function synergistically to promote glucose production. J Biol Chem 285(46):35245–35248. https://doi.org/10.1074/jbc.C110.175851

5. Zhang K, Li L, Qi Y et al (2012) Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice. Endocrinology 153(2):631–646. https://doi.org/10.1210/en.2011-1527

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