The non-canonical NF-κB pathway is induced by cytokines in pancreatic beta cells and contributes to cell death and proinflammatory responses in vitro-Reference-Cited by-同舟云学术

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The non-canonical NF-κB pathway is induced by cytokines in pancreatic beta cells and contributes to cell death and proinflammatory responses in vitro

Published:2015-12-03 Issue:3 Volume:59 Page:512-521
ISSN:0012-186X
Container-title:Diabetologia
language:en
Short-container-title:Diabetologia

Author:

Meyerovich Kira,Fukaya Makiko,Terra Leticia F.,Ortis Fernanda,Eizirik Decio L.,Cardozo Alessandra K.

Funder

Actions de Recherche Concertees de la Communaute Francaise (ARC)

Coordenação de Aperfeiçoamento de Pessoal de Nivel Superior (CAPES)

Seventh Framework Programme

Fundação de Auxilio a Pesquisa do Estado de São Paulo (FAPESP)

Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture

Juvenile Diabetes Research Foundation International

Publisher

Springer Science and Business Media LLC

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

http://link.springer.com/content/pdf/10.1007/s00125-015-3817-z.pdf

Reference50 articles.

1. Eizirik DL, Colli ML, Ortis F (2009) The role of inflammation in insulitis and β-cell loss in type 1 diabetes. Nat Rev Endocrinol 5:219–226

2. Cardozo AK, Heimberg H, Heremans Y et al (2001) A comprehensive analysis of cytokine-induced and nuclear factor-κB-dependent genes in primary rat pancreatic β-cells. J Biol Chem 276:48879–48886

3. Grieco FA, Vendrame F, Spagnuolo I, Dotta F (2011) Innate immunity and the pathogenesis of type 1 diabetes. Semin Immunopathol 33:57–66

4. Eldor R, Yeffet A, Baum K et al (2006) Conditional and specific NF-κB blockade protects pancreatic beta cells from diabetogenic agents. Proc Natl Acad Sci U S A 103:5072–5077

5. Salem HH, Trojanowski B, Fiedler K et al (2014) Long-term IKK2/NF-κB signaling in pancreatic β-cells induces immune-mediated diabetes. Diabetes 63:960–975

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