GLP-1 signalling compensates for impaired insulin signalling in regulating beta cell proliferation in βIRKO mice

Author:

Kawamori Dan,Shirakawa Jun,Liew Chong Wee,Hu Jiang,Morioka Tomoaki,Duttaroy Alokesh,Burkey Bryan,Kulkarni Rohit N.

Funder

Japan Society for the Promotion of Science

Uehara Memorial Foundation

Novartis Institutes for Biomedical Research Inc.

National Institute of Diabetes and Digestive and Kidney Diseases

Manpei Suzuki Diabetes Foundation, Japan

Publisher

Springer Science and Business Media LLC

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Reference50 articles.

1. Kahn CR, Weir GC, King GL, Jacobson AM, Moses AC, Smith RJ (2005) Diabetes mellitus. Lippincott, Williams and Wilkins, New York

2. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC (2003) Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52:102–110

3. Drucker DJ (2006) The biology of incretin hormones. Cell Metab 3:153–165

4. Stoffers DA, Kieffer TJ, Hussain MA et al (2000) Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes 49:741–748

5. Habener JF, Stoffers DA (1998) A newly discovered role of transcription factors involved in pancreas development and the pathogenesis of diabetes mellitus. Proc Assoc Am Physicians 110:12–21

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