Weekly injection of IL-2 using an injectable hydrogel reduces autoimmune diabetes incidence in NOD mice

Author:

Nagy NadineORCID,Kaber GernotORCID,Kratochvil Michael J.ORCID,Kuipers Hedwich F.ORCID,Ruppert Shannon M.,Yadava KoshikaORCID,Yang JasonORCID,Heilshorn Sarah C.ORCID,Long S. AliceORCID,Pugliese AlbertoORCID,Bollyky Paul L.ORCID

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Harrington Institute

National Institutes of Health

Stanford Child Health Research Institute

Stanford SPARK

Child Health Research Institute and the Stanford NIH-NCATS-CTSA

JDRF

Publisher

Springer Science and Business Media LLC

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Reference26 articles.

1. Bollyky PL, Falk BA, Long SA et al (2009) CD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta. J Immunol 183(4):2232–2241. https://doi.org/10.4049/jimmunol.0900191

2. Bayer AL, Yu A, Malek TR (2007) Function of the IL-2R for thymic and peripheral CD4+CD25+ Foxp3+ T regulatory cells. J Immunol 178(7):4062–4071. https://doi.org/10.4049/jimmunol.178.7.4062

3. Rosenzwajg M, Churlaud G, Mallone R et al (2015) Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients. J Autoimmun 58:48–58. https://doi.org/10.1016/j.jaut.2015.01.001

4. Lotze MT, Frana LW, Sharrow SO, Robb RJ, Rosenberg SA (1985) In vivo administration of purified human interleukin 2. I. Half-life and immunologic effects of the Jurkat cell line-derived interleukin 2. J Immunol 134(1):157–166

5. Cheever MA, Thompson JA, Kern DE, Greenberg PD (1985) Interleukin 2 (IL 2) administered in vivo: Influence of IL 2 route and timing on T cell growth. J Immunol 134:3895–3900 https://www.jimmunol.org/content/134/6/3895

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