Preclinical and phase I trials of topoisomerase I inhibitors

Author:

Von Hoff Daniel D.,Burris Howard A.,Eckardt John,Rothenberg Mace,Fields Suzanne M.,Chen Shih-Fong,Kuhn John G.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference23 articles.

1. Abigerges D, Armand JP, Chabot GG, Cote C, Rougier P, Concalves E, Fadel E, Herait P, Gandia D (1993) High dose intensity of CPT-11 administered as a single dose every 3 weeks: the Institut Gustave Roussy experience. Proc Am Soc Clin Oncol 12:133

2. Bissery MC, Nguyen CH, Bisagni E, Lavelle F (1990) Preclinical evaluation of RP 60475, a pyrido-benzo-indole antitumor agent. Proc Am Assoc Cancer Res 31:2747

3. Burris HA III, Hanauske A-R, Marshall MH, Kuhn JG, Hilsenbeck SG, Von Hoff DD (1992) Activity of topotecan, a new topoisomerase I inhibitor, against human tumor colony-forming units in vitro. J Natl Cancer Inst 84:1816

4. Burris H, Kuhn J, Wall J, Eckardt J, Rodriguez G, Johnson R, Weiss G, Shaffer D, Von Hoff D (1992) Early clinical trials of topotecan, a new topoisomerase I inhibitor. Ann Oncol 3 [Suppl 1]:118

5. Chen S-F, Rothenberg ML, Clark G, Degen D, Wajima M, Barton D, Von Hoff DD (1994) Human tumor carboxylesterase activity correlates with CPT-11 cytotoxicity in vitro. Proc Am Assoc Cancer Res 35:2174

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